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CMBI Advanced Retrosynthesis Lecture notes Disconnection Approach Introduction to chemical synthesis - Format: PDF Putting Reactions Together Synthesis and Retrosynthesis.
The reaction sequence for synthesis of tert-butanol from methylpropane, based on the retrosynthetic analysis above.
Retrosynthetic analysis is a technique for solving problems in the planning of organic syntheses.
Thus, if we form two Br bonds to each of the carbons, we can then form the alkyne from 1,2-dibromo-3,3dimethylbutane.
In the forward reaction, we can do this with a strong base such as sodium ethoxide (Na OEt) in ethanol to form the alkyne. To do this, we would have to carry out an addition reaction.
This is achieved by transforming a target molecule into simpler precursor structures regardless of any potential reactivity/interaction with reagents.
Each precursor material is examined using the same method.
Let’s take a look at the retrosynthesis of 3,3-dimethylbutyne from 3,3 dmethylbutanol.
At first you may see the reagent has an alcohol group but maybe you wonder “how am I going to get to an alkyne, we haven’t even seen alkynes yet!
The retrosynthetic analysis is not a synthesis form of organic chemistry, but an analytical approach based on the desired product.
The target molecule is broken down into smaller and smaller fragments.